Gene: TP53 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121912654
rs121912654
TP53
0.010 GeneticVariation BEFREE The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. 31067569

2020
dbSNP: rs483352697
rs483352697
TP53
0.010 GeneticVariation BEFREE The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. 31067569

2020
dbSNP: rs28934576
rs28934576
TP53
0.030 GeneticVariation BEFREE H1299 p53 null lung cancer cells were stably transfected with R273H mutant GOF-p53 or wild-type (wt) p53 or empty vectors. 30723502

2019
dbSNP: rs11540652
rs11540652
TP53
0.020 GeneticVariation BEFREE It is shown that this biosensor preferentially reports on the p53 R248Q mutant in the PC9 lung cancer cell line compared with other lung cancer cell lines harbouring either wild-type or no p53. 30548750

2019
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE TP53 p.R72P genotype is a marker of poor prognosis in lung cancer. 29286914

2018
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE TP53 p.R72P genotype is a marker of poor prognosis in lung cancer. 29286914

2018
dbSNP: rs878854066
rs878854066
TP53
0.100 GeneticVariation BEFREE TP53 p.R72P genotype is a marker of poor prognosis in lung cancer. 29286914

2018
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence. 28827732

2017
dbSNP: rs28934578
rs28934578
TP53
0.030 GeneticVariation BEFREE We show that lung epithelial expression of R270H and R172H (R273H and R175H in humans), common TRP53 mutants in lung cancer, combined with RB1 loss selectively results in two subtypes of neuroendocrine carcinoma, SCLC and large cell neuroendocrine carcinoma (LCNEC). 28847987

2017
dbSNP: rs587782596
rs587782596
TP53
0.010 GeneticVariation BEFREE We further tested 85 unrelated Arab cancer patients and father of a BC carrier patient for TP53 c.541C>T using a real time polymerase chain reaction (RT-PCR) approach and identified four additional carriers, two with BC one with lung cancer, and the father of a BC carrier patient, diagnosed with GBM. 27866339

2017
dbSNP: rs762846821
rs762846821
TP53
0.030 GeneticVariation BEFREE In this study, we have investigated the delivery and transfection of wild-type (wt-) p53 and microRNA-125b (miR-125b) expressing plasmid DNA, in SK-LU-1 human lung adenocarcinoma cells as well as in Kras(G12D)/p53(fl/fl) (KP) genetically engineered mouse model of lung cancer. 26686386

2016
dbSNP: rs28934578
rs28934578
TP53
0.030 GeneticVariation BEFREE Ecotopic expression of wild-type p53, but not mutant p53 (R175H) suppressed both endogenous and exogenous 14-3-3γ in colon and lung cancer cell lines. 25384678

2015
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE We used real-time PCR method to investigate the genotypic frequencies of rs2602141, rs560191 and rs689647 in 53BP1 and rs1042522 in TP53 in 640 cases of lung cancer and 685 controls. 24316395

2014
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE We conclude that not Pro47Ser SNP but Arg72Pro SNP is involved in susceptibility to developing lung cancer, at least in Bangladeshi population. 25034526

2014
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE We conclude that not Pro47Ser SNP but Arg72Pro SNP is involved in susceptibility to developing lung cancer, at least in Bangladeshi population. 25034526

2014
dbSNP: rs878854066
rs878854066
TP53
0.100 GeneticVariation BEFREE We conclude that not Pro47Ser SNP but Arg72Pro SNP is involved in susceptibility to developing lung cancer, at least in Bangladeshi population. 25034526

2014
dbSNP: rs1800371
rs1800371
TP53
0.010 GeneticVariation BEFREE We conclude that not Pro47Ser SNP but Arg72Pro SNP is involved in susceptibility to developing lung cancer, at least in Bangladeshi population. 25034526

2014
dbSNP: rs863224682
rs863224682
TP53
0.010 GeneticVariation BEFREE The above results suggest that an FGFR3 p.R248H mutation is involved in the carcinogenesis of a subset of LCs and may contribute to the elucidation of the characteristics of FGFR3 mutation-positive LCs in the future. 24452392

2014
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE We performed a meta-analysis to evaluate the relationship between TP53 Arg72Pro polymorphism and lung cancer susceptibility basing on 15,647 lung cancer patients and 14,391 controls from 36 published literatures. 23595658

2013
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population. 23812725

2013
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G>C) of the p53 gene with lung cancer susceptibility using 175 cancer cases and 202 controls from the North Indian population. 23317414

2013
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE The variant genotype of TP53 SNP rs1042522 significantly increased lung cancer risk in the total population (OR: 1.57, 95% CI: 1.11-2.21), but there was no evidence of heterogeneity among individuals with different lifestyle factors. 24369748

2013
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE We performed a meta-analysis to evaluate the relationship between TP53 Arg72Pro polymorphism and lung cancer susceptibility basing on 15,647 lung cancer patients and 14,391 controls from 36 published literatures. 23595658

2013
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G>C) of the p53 gene with lung cancer susceptibility using 175 cancer cases and 202 controls from the North Indian population. 23317414

2013
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population. 23812725

2013